News

Dr. Parello Presents at Taconic Microbiome Research Symposium

Released on October 26, 2016

On Thursday, November 17th, at 10:35am, Dr. Caitlin SL Parello will be giving a 20 minute presentation titled “Utilizing Gnotobiotic Mice to Understand the Role of the Microbiome in Murine Disease Models.”   If you’re interested in meeting with Dr. … Continue reading

Biomodels enters the germ-free and gnotobiotic research space!

Released on October 3, 2016

The environmentally exposed surfaces of mammals are colonized by a diverse ecosystem of microbes. Though many of these bacteria – particularly those of the distal gut – are considered symbiotic, the microbiome has the capacity to induce both pro- and … Continue reading

Ben Cuiffo, Ph.D., Bloomberg Business Week

Released on October 3, 2016

  In early 2016 Biomodels opened their Gnotobiotic isolator facility for Germ-Free and Gnotobiotic murine models. Biomodels has from the start sourced their Germ-Free mice from Taconic Biosciences.  In a recent interview with Bloomberg Businessweek at a Taconic Microbiome conference, Biomodels … Continue reading

November Webinar: Leveraging New and Established Preclinical Oncology Models for Translational Success

Released on September 26, 2016

WEBINAR DETAILS November 10, 2016, 11am EST REGISTER NOW   The success rate of anti-cancer therapeutics has historically been low, hovering around 5%, and may attributed to the widespread use of imperfect models in the preclinical phase. We will discuss … Continue reading

October Webinar: Immunological Methods- Understanding and Enhancement of Pre-clinical Animal Models of Disease

Released on September 14, 2016

WEBINAR DETAILS October 13, 2016, 1pm EST VIEW WEBINAR   Aspects of both the innate and adaptive immune systems are involved in the vast majority of animal disease models. Knowledge of the immunological mechanisms involved in the pathogenesis of disease … Continue reading

September Webinar: Utilizing Gnotobiotic Mice to Understand the Role of the Microbiome in Murine Disease Models

Released on August 10, 2016

  WEBINAR DETAILS September 15, 2016, 11am EST VIEW WEBINAR   The environmentally exposed surfaces of mammals, such as the skin, mouth, gut, and vagina, are colonized by a diverse ecosystem of microbes. Though many of these bacteria – particularly … Continue reading

Dr. Beal Attends DoT 2016

Released on June 3, 2016

Dr. Dominic Beal attends the 14th Annual Discovery on Target Conference, September 19-22, 2016.   If you’re interested in meeting with Dr. Beal at the meeting please email Ashlee Coyne (Business Development) directly to schedule a meeting,  acoyne@biomodels.com.   Meeting Location: Westin Boston Waterfront, Boston, MA … Continue reading

Biomodels Attends IRA 2016

Released on June 3, 2016

Biomodels attends the 19th Inflammation Research Association (IRA) International Conference, September 20-21, 2016.   Please come by Biomodels booth (# TBD) to meet with our team, alternatively if you prefer to schedule a meeting please email Ashlee Coyne (Business Development) directly, … Continue reading

Biomodels Sponsored Talk at WPC 2016

Released on June 3, 2016

Biomodels Presents at the 5th Annual World Preclinical Congress 2016, Part 1: Preclinical Models in Oncology Conference Track.   On Wednesday, June 15, at 11:50am, Dr. Benjamin G. Cuiffo will be giving a 15 minute presentation titled “Current Preclinical Models of Oncology: … Continue reading

Dr. Parello presents at 2nd Annual Translational Microbiome Conference

Released on April 12, 2016

Dr. Caitlin S.L. Parello  will present “An Assessment of Microbiome Significance in GVHD and Melanoma Xenograft Murine Models.”   Meeting will be held April 20-21, 2016 at the Hilton, Boston Back Bay.    

May Webinar: Precision Medicine in Cancer Supportive Care

Released on March 29, 2016

WEBINAR DETAILS May 12, 2016, 11am EDT VIEW  WEBINAR   Cancer regimen-related toxicities are often devastating consequences of current chemo- and radiotherapy regimens used for the treatment of malignancies. But not all patients are at equal risk for developing toxicities … Continue reading

Dr. Paulette Wright Andreotta presents at ATS 2016

Released on March 25, 2016

Dr. Paulette Wright Andreotta will present “A Rat Model of Severe Allergic Asthma”   Session Details: Tuesday, May 17, 2016, 9:00am-4:15pm, Code C36, Novel Mechanisms of Allergic Airway Inflammation in Animal Models.  

Dr. Cuiffo Presents at AACR 2016

Released on March 25, 2016

Dr. Benjamin G. Cuiffo will present “Gene-expression characterization of bioluminescent PDX in orthotopic and ectopic models of pancreatic cancer and metastatic triple-negative breast cancer.” Session Details: Sunday April 17, 2016, 1:00pm-5:00pm, Tumor Biology (Category), Human in Mouse Models (Title), Halls G-J, Poster … Continue reading

Dr. Cuiffo presents at AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics

Released on October 6, 2015

  Dr. Benjamin G. Cuiffo will present “Bioluminescent Orthotopic PDX models of primary pancreatic cancer and residual/metastatic breast cancer predict efficacy of standard of care and experimental treatments.” Poster session: A, titled “Animal Models”, Friday November 6th, 2015, 12:15pm-3:15pm, Exhibit … Continue reading

September Webinar: Current Preclinical Models in Oncology – Enhancing Predictivity for Translational Success

Released on August 12, 2015

  WEBINAR DETAILS September 24, 2015, 11am EDT REGISTER NOW   The success rate of potential novel anti-cancer therapeutics has historically been low, hovering around 5%, and is attributed, at least in part, to the widespread use of readily available … Continue reading

Dr. Beal and Dr. Andreotta Present at WCI 2015

Released on July 14, 2015

12th World Congress on Inflammation (WCI) meeting, Seaport Hotel and World Trade Center, Boston, MA.   Dr. Dominic R. Beal will be presenting “Enhancements to the Predictability and Clinical Relevance of Two Murine Models of Chronic Inflammation: Adoptive Transfer-Induced Colitis and … Continue reading

June Webinar: Predictive Preclinical Animal Models of Pulmonary Disease: Acute & Severe Asthma, Pulmonary Fibrosis, Acute Lung Injury (ALI) & Acute Respiratory Distress Syndrome (ARDS)

Released on May 22, 2015

  WEBINAR DETAILS June 25, 2015 at 11am EDT REGISTER NOW   Pulmonary disease is among the leading causes of death in the United States and is responsible for more than $150 billion in healthcare costs; with increasing incidences of … Continue reading

Biomodels Sponsored Talk at WPC 2015

Released on May 22, 2015

Biomodels Presents at the Annual World Preclinical Congress 2015, as part of the Novel Preclinical Models in Oncology Conference Track.   On Wednesday, June 10, at 11:50am, Dr. Benjamin G. Cuiffo will be giving a 15 minute presentation titled “Evaluating … Continue reading

Mechanisms of cellular fibrosis associated with cancer regimen-related toxicities

Released on April 3, 2015

MARIA L. MANCINI AND STEPHEN T. SONIS | APRIL 1, 2015   ABSTRACT Fibrosis is a common, persistent and potentially debilitating complication of chemotherapy and radiation regimens used for the treatment of cancer. The molecular mechanisms underlying fibrosis have been … Continue reading

Last Webinar of 2014, “Preclinical Models Designed for the Development of Treatment Strategies for a Range of Radiation-Induced Tissue Toxicities”

Released on October 21, 2014

Ionizing radiation, whether in the context of radiotherapy or from unplanned or purposeful environmental exposure (i.e. Fukushima or dirty bomb), results in a sequence of biological events that create a host of clinically significant consequences that range in severity from … Continue reading

Dr. Arold and Dr. Beal Present at IRA 2014

Released on August 20, 2014

Inflammation Research Association (IRA), Annual Meeting, September 16-17, Menlo Park, CA.   Dr. Stephen Arold will be presenting “Pirfenidone and anti-TGFβ Therapies Ameliorate Bleomycin Induced Decline in Lung Function in Mice.”        Dr. Dominic Beal will be presenting … Continue reading

3rd Webinar of 2014, “Immunological Methods to Enhance Translatability of Pre-clinical Models of GVHD and IBD”

Released on August 19, 2014

Knowledge of the involvement of the innate and adaptive immune systems is relevant to the vast majority of disease models. Consequently the ability to integrate advanced immunological methods into pre-clinical models of disease markedly enhances their predictive value in the … Continue reading

Biomodels second Webinar of 2014, “Preclinical Models of Lung Inflammatory Disease”

Released on May 15, 2014

Pulmonary disease is among the leading causes of death in the United States and is responsible for more than $150 billion in healthcare costs; with increasing incidences of COPD, asthma and idiopathic pulmonary fibrosis the need to develop innovative therapeutic … Continue reading

Dr. Sonis presents at ASCO 2014 on Supportive Care in Head & Neck Cancer

Released on May 15, 2014

Dr. Sonis will be presenting “Supportive Care in the Head and Neck Cancer Patient: A Case-Based Discussion from Diagnosis to Survivorship.” Clinical Problems in Oncology (session), Toxicity Management in Head and Neck Cancer, June 1, 2014, 9:45am-11:00am.   Session ticket … Continue reading

Dr. Stephen T. Sonis presents at MASCC/ISOO International Symposium on Supportive Care in Cancer

Released on May 15, 2014

Dr. Sonis will be presenting “Toxisomes: Genetics, Inflammation and Regimen-related Toxicities.” Session information: June 27, 2014, 3:45pm-5:15pm, Mucositis (Parallel session).

Biomodels sponsored presentation at WPC 2014

Released on March 25, 2014

Biomodels sponsored presentation is part of WPC’s Tumor Models for Targeted Therapy conference track. On Wednesday, May 21, at 4:05pm, Dr. Mancini will be giving a 15 minute presentation titled “Modeling Human Cancer: A Multifaceted Approach to Pre-Clinical Development.”   … Continue reading

Biomodels presents at annual ATS meeting 2014

Released on March 25, 2014

Biomodels presents at the American Thoracic Society (ATS) Annual Meeting, May 16-21, 2014. Dr. Stephen Arold will be presenting  “Inflammatory Cell Influx Correlates with Alterations in Lung Mechanics and In Vivo Imaging of Inflammatory Mediators in Mouse Models of Acute … Continue reading

Biomodels presents, “Modeling Human Cancer: A Multidisciplinary Approach”. First webinar of 2014

Released on March 20, 2014

There are a variety of ways to study human cancer progression and test potential therapeutics using translational animal models. Choosing the right animal model is critical to transition preclinical success in mouse/rat studies to success in human patients. It is … Continue reading

Awarded the Best Original Article published by Oral Diseases (2013)

Released on February 2, 2014

ST Sonis, JH Antin, MW Tedaldi and G Alterovitz have received the Award for the Best Original Article Published by Oral Diseases during the year 2013. The award was given for the article SNP-based Baysian networks can predict oral mucositis … Continue reading

Biomodels presents at AACR annual meeting 2014

Released on January 13, 2014

Biomodels presents at the AACR Annual Meeting 2014: Biomodels is attending the AACR annual meeting 2014 in San Diego, April 5-9th (Booth # 513). At the conference, Dr. Mancini is presenting “Modeling the Differential Responses of Cancer Stem Cells (CSCs) … Continue reading

Biomodels, LLC and Numira INC sign joint services agreement

Released on January 8, 2014

Watertown, MA and Salt Lake City, UT, January 6, 2014. Biomodels, a front-runner and innovator in translational pre-clinical efficacy models and genomics, today announced the signing of a joint services agreement with Numira Inc, the market leader in high-resolution, 3D … Continue reading

Biomodels presents at the molecular med tri-conference 2014

Released on January 8, 2014

Biomodels presents at the molecular med tri-conference 2014: Biomodels is attending the Molecular Med Tri-Conference 2014 in San Francisco Feb 9th – 14th. At the conference, Dr. Mancini is presenting “Modeling the Differential Responses of Cancer Stem Cells (CSCs) as … Continue reading

Biomodels is hosting their second webinar of the year

Released on August 23, 2013

On September 10th at 1PM EST, Biomodels is hosting their second webinar of the year entitled “Inflammatory Bowel Disease: Utilization of Experimental Colitis Models to Transition Novel Therapies from a Concept to Patients” For more information and free registration click … Continue reading

Biomodels’ Team presents Webinar “Novel Opportunities for the Development of Drug and Biologics in Cancer Supportive Care”

Released on June 27, 2013

Synopsis: While innovative therapeutic options have resulted in increasing successes in cancer treatment, the collateral damage associated with cancer regimen-related toxicities is profound. Almost three quarters of patients undergoing cancer therapy develop treatment-associated side effects of such severity as to … Continue reading

Steve Sonis presents at MASCC 2013 in Berlin, Germany

Released on June 27, 2013

Dr. Sonis presented at MASCC 2013: “How Cancer Treatment-Induced Biological Signaling Impacts Patients Outcomes”

Steve Sonis Delivers Key Note Address at Gordon Conference

Released on June 27, 2013

Dr. Sonis delivered the key note address at the Gordon Research Conference on Mucosal Health and Disease in June.  Additionally at the Gordon Research Conference, he presented “Translating the science: Risk prediction for toxicities caused by cancer therapies”

Biomodels Presenting at the 59th Annual Radiation Research Society Meeting

Released on June 27, 2013

The Biomodels team will attend the 59th Annual RRS Meeting on September 14-18th Dr. Maria Mancini will present: “Changes in Levels of Plasma Citrolline as a Biomarker for Acute Radiation Syndrome”   (Session PS2) “Rodent models of acute and fractionated radiation-induced … Continue reading

Biomodels is pleased to announce the publication of Pathobiology of Cancer Regimen-Related Toxicities

Released on February 11, 2013

Springer Publishing Company recently announced the publication of “Pathobiology of Cancer Regimen-Related Toxicities, a book co-edited by Dr. Stephen Sonis, Biomodels’ CSO and Dr. Dorothy Keefe, Professor of Cancer Medicine at the University of Adelaide. Translational models of toxicities of … Continue reading

BIOMODELS PRESENTS AT THE MOLECULAR MED TRI-CON 2013

Released on February 1, 2013

Biomodels is attending the Molecular Med Tri-Con 2013 in San Francisco Feb 11th – 15th. At the conference, Dr. Mancini is presenting “Animal Models of Colorectal Cancer”(Poster #7) highlighting Biomodel’s preclinical data on three colon cancer models using the established … Continue reading

BIOMODELS PRESENTS AT THE SOCIETY FOR NEUROSCIENCE CONFERENCE

Released on October 20, 2012

Biomodels attended the Society for Neuroscience conference in New Orleans.  At the conference, Dr. Zombeck presented a poster titled “A mouse model of anemia-independent chemotherapy-related fatigue (CRF).”  The abstract for the poster can be found on the Society for Neuroscience … Continue reading

BIOMODELS PRESENTS AT THE MULTINATIONAL ASSOCIATION OF SUPPORTIVE CARE IN CANCER CONFERENCE

Released on September 13, 2012

Biomodels recently attended the Multinational Association of Supportive Care in Cancer (MASCC) conference in New York. Dr.Sonis gave an oral presentation on using molecular predictors in supportive care. An oral presentation was also given by Dr. Mancini who spoke on … Continue reading

BIOMODELS EXPANDS LABORATORY AND OFFICE SPACE

Released on September 13, 2012

Biomodels added 6600 square feet of space to its facility, effectively doubling in size! The new space includes a renovated reception area, conference rooms, offices, and additional laboratory space. This has enabled Biomodels to increase the animal holding space, therefore … Continue reading

BIOMODELS/IBD COLITIS RESEARCH COLLABORATION IN PNAS PUBLICATION

Released on March 7, 2011

Biomodels would like to announce the publication of an important manuscript in PNAS that explores the potential role of mast cell tryptase in the development and severity of Inflammatory Bowel Disease (including Crohn’s Disease and Ulcerative Colitis). This manuscript was … Continue reading

CIT and BioModels Announce Alliance

Released on December 14, 2010

Skills in providing efficacy models combined with GLP toxicology know-how will provide clients with seamless development services Evreux, France and Watertown, MA, USA, December 16, 2010 – CIT, the preclinical drug safety CRO based outside Paris, and Biomodels, the Boston-based … Continue reading

Swedish Orphan Biovitrum and Biomodels to Develop Assay For Mucositis Risk In Cancer Treatment

Released on May 11, 2010

Stockholm, Sweden and Watertown, MA, USA – May 11, 2010 – Swedish Orphan Biovitrum (STO: BVT) and Biomodels LLC today announced a research agreement, under which Biomodels will explore the possibility of developing a clinically applicable screening platform that will … Continue reading

Biomodels Scientists Report Development of a Novel Model for Cancer Treatment-Related Fatigue

Released on November 16, 2009

Research Opens Door for Developing New Treatments Boston, MA (November 16, 2009) — Scientists at Biomodels have successfully developed the first model that accurately duplicates human cancer treatment-related fatigue (CTRF). The new model shows, that as in human cancer patients, … Continue reading

Lubris, Biomodels Report On Potential New Therapy For Osteoarthritis

Released on October 27, 2009

Medical researchers will report findings (Oct. 19) that demonstrate that injecting the protein lubricin into knee joints can dramatically reduce cartilage degeneration. The discovery by scientists at Biomodels, a preclinical drug research organization, and Lubris, a Massachusetts-based startup company, could … Continue reading

Avaxia Biologics Awarded Phase I SBIR Grant to Develop Antibody Therapeutic for Oral Mucositis

Released on September 17, 2009

Collaboration with Biomodels facilitates development of novel drug product. BURLINGTON, MA (Sept. 16) Avaxia Biologics, Inc., a biotechnology company developing oral antibodies for disease targets accessible via the GI tract, announced today that it has been awarded a Phase I … Continue reading

Biomodels’ Oral Mucositis Expertise Speeds FDA Approval for ActoGeniX’s Phase 1b Trial of AGO13 in Cancer Patients

Released on June 22, 2009

ActoGeniX taps Biomodels CRO expertise in $1 billion market for cancer support care to relieve side effects of cancer treatments WATERTOWN, Mass., June 22 /PRNewswire/ — Biomodels LLC, a preclinical research organization specializing in cancer support care, today announced that … Continue reading

Applied Protein Sciences and Biomodels Collaborate to Boost Supportive Cancer Care

Released on April 28, 2009

MOUNTAIN VIEW, Calif.–(Business Wire)– Applied Protein Sciences, a biotechnology start-up focused on preventing mucositis, announced today that it has entered into a strategic alliance with Biomodels. This alliance allows speedier product development and helps APS expand its pipeline to develop … Continue reading