Wheel Running

Clinical Background

Rodents show a strong circadian rhythm in voluntary wheel running behavior. Wheel running activity is monitored over several days or weeks for the purpose of assessing drug effects on exercise behavior. Wheel running measurements may be used in studies of toxicity, circadian rhythm, and voluntary exercise.

Circadian Rhythm of Wheel Running Activity

Plot shows mean activity in 15 minute bins over the course of 24 hours. The black bar at the top of the graph represents the dark phase of the light/dark cycle.