September Webinar: Utilizing Gnotobiotic Mice to Understand the Role of the Microbiome in Murine Disease Models



September 15, 2016, 11am EST



The environmentally exposed surfaces of mammals, such as the skin, mouth, gut, and vagina, are colonized by a diverse ecosystem of microbes. Though many of these bacteria – particularly those of the distal gut – are considered symbiotic, the microbiome has the capacity to induce both pro- and anti- inflammatory responses. Accumulating evidence suggests that a properly balanced gut microbiome is crucial for a correctly functioning immune system, and that imbalances in the microbial community of the intestine are linked to a multitude of auto-inflammatory and auto-immune diseases. This symposium will discuss the roles of the microbiome in murine models of various inflammatory disease states, and the advantages to utilizing germ-free/gnotobiotic mice when probing disease models with a microbiome component.