Introduction

Diabetes is a disease in which the body fails to regulate blood sugar adequately.  Type 1 diabetes is caused by a failure to produce sufficient insulin, the hormone that is primarily responsible for the regulation of blood sugar, and Type 2 diabetes is a failure to respond to insulin.

Approximately 7.8% of the US population has diabetes, while almost twice that number is estimated to suffer from pre-diabetes, a precursor condition to full-blown diabetes. Obesity is a major risk factor for diabetes.

Insulin therapy can help control blood sugar levels, but patients with Type 2 diabetes are often insulin resistant.

Poorly controlled diabetes can lead to a host of complications including hypertension, heart disease and stroke, kidney disease and failure, diabetic neuropathy and retinopathy and diabetic ulcers.

Animal Models of Diabetes

There are numerous genetic models of diabetes in both rats and mice, including the Zucker and ZDF rats and ob/ob and db/db mice in which diabetes develops spontaneously. There are also models of diet-induced diabetes, in which the development of diabetes is a secondary consequence of obesity. Diabetes can also be induced by treatment with chemicals, such as streptozotocin, which ablates the insulin producing cells of the pancreas, thereby inducing diabetes. All of these models can be used to evaluate the different aspects of diabetes, whether testing novel therapeutic compounds that help control blood glucose levels in a simple oral glucose tolerance test, or evaluating compounds to treat one of complications of diabetes, such as diabetic ulcer, Biomodels has the experience and expertise to help our clients select and run the appropriate study.

Preclinical Diabetes Research by Biomodels

With so many people affected by diabetes each and every day, medical advancements and pharmaceuticals are increasingly important to preserve the health of those currently struggling with the disease and for future individuals that may become affected by it. There are a number of pharmaceutical companies out there developing medicine for those dealing with type 1 or type 2 diabetes that require preclinical research before getting into the hands of our people.

There are a number of causes of diabetes and whether it is a genetic issue or a dietary issue, individuals suffering from diabetes deserve the best in pharmaceuticals to combat their problem. Due to this, the need for preclinical diabetes research is more important now than ever. There will always be new findings with the disease, so it is important that you have a preclinical research company ready to take on pharmaceutical advancements.

If you are a pharmaceutical company developing medicines to combat diabetes and are in need of preclinical diabetes research, you have come to the right place. Independently founded and providing professionals with preclinical research services for over 10 years, Biomodels is trusted by both small and large pharmaceutical companies nationwide.

For the best in preclinical diabetes research, type 1 diabetes research, and type 2 diabetes research, trust in Biomodels, offering fast, innovative, and predictive services. If you are ready to utilize Biomodels for your preclinical diabetes research, contact us today. We can be reached via our online contact form on this page (also located on our contact page). Feel free to complete the form with any questions and someone from Biomodels will be in contact with you shortly.