June Webinar: Predictive Preclinical Animal Models of Pulmonary Disease: Acute & Severe Asthma, Pulmonary Fibrosis, Acute Lung Injury (ALI) & Acute Respiratory Distress Syndrome (ARDS)

 

WEBINAR DETAILS

June 25, 2015 at 11am EDT

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Pulmonary disease is among the leading causes of death in the United States and is responsible for more than $150 billion in healthcare costs; with increasing incidences of COPD, asthma and idiopathic pulmonary fibrosis the need to develop innovative therapeutic options for the treatment of these inflammatory lung diseases is imperative.

Historically animal models of respiratory disease have relied heavily on endpoints of histology, mediator analysis and in cases such as asthma, measures of airway hyperresponsiveness. However a more relevant translational model must evaluate not only the inflammation and pathology but how the underlying disease affects the mechanical properties of the lung, therefore displaying the interdependence of lung mechanics and pulmonary inflammation. This webinar will showcase translational and predictive animal models of pulmonary disease that focus on both the underlying inflammatory process as well as how the degree and type of inflammation influence changes in lung compliance and airway hyperactivity. Additionally, the webinar will provide an overview of each clinical condition and how the utilization of both traditional and functional analyses in our animal models result in outcomes that will best predict disease severity and ultimately how therapeutics will behave in the clinic.