Alcoholism

Alcoholism is a widespread disorder characterized by compulsive and uncontrolled consumption of alcohol. The impact of repeated heavy use of alcohol can be devastating. Possible implications include cirrhosis of the liver, pancreatitis, epilepsy, and damage to the nervous system. Currently, very few pharmaceutical interventions are available to help prevent alcohol consumption.

Drinking in the Dark (DID)

Biomodels uses the Drinking in the Dark (DID) mouse model of alcoholism. In this model, C57BL/6J mice voluntarily drink ethanol to intoxication when access is limited to a few hours during the dark cycle.. Currently prescribed alcoholism medications, acamprosate and naltrexone, have been shown effective in the DID model. Biomodels has studied the effect of topiramate, an anticonvulsant drug with successful clinical data for alcoholism, in the DID model. The results showed that topiramate is effective in reducing alcohol intake, but not water or saccharin intake.

Study Design Table

Model Description Study Length Endpoints
Drinking in the Dark (DID) Ethanol access is limited to 2-4 hrs/day resulting in voluntary consumption to clinically relevant levels of intoxication. 7 days Ethanol consumption

 

The Effect of Topiramate on Ethanol Consumption
The Effect of Topiramate on Water Consumption
The Effect of Topiramate on Saccharin Consumption
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