Syngeneic Models of Cancer

We recognize that some anti-cancer molecules work in combination with the host immune system. In xenograft systems, where athymic or nude mice are the host animal, drugs may not function properly, if at all. We offer synegenic models of cancer that are especially useful in evaluating the action of a potential novel therapeutic.  Biomodels offers syngeneic models of breast, colon and lung cancer, melanoma and glioma in either rats or mice.

Syngeneic models of cancer can be especially useful when the molecule under evaluation interacts with the host immune system. In this situation, using athymic or SCID mice may prevent a drug from working properly, and using a syngeneic model where animal has a complete and intact immune system can allow for a more accurate evaluation of the.  
 

Orthotopic Model of Glioma. F98 cells were implanted directly into the cranium of anesthetized Sprague Dawley rats using a Hamilton syringe. Seven days post-implantation, animals were administered a single, focused dose of radiation. At the onset of neurological symptoms, animals were euthanized and brains were perfused, fixed in formalin, and stained with H & E (Top panels). Areas of hemorrhage (arrowheads) and tumor masses (arrows) were clearly visible. Survival curve (Bottom panel).