BIOMODELS/IBD COLITIS RESEARCH COLLABORATION IN PNAS PUBLICATION

Biomodels would like to announce the publication of an important manuscript in PNAS that explores the potential role of mast cell tryptase in the development and severity of Inflammatory Bowel Disease (including Crohn’s Disease and Ulcerative Colitis). This manuscript was published based on the work from a collaboration between Biomodels’ Scientist Gregory D. Lyng, Ph.D. and Matthew J. Hamilton, M.D. and colleagues at Brigham & Women’s Hospital in Boston, MA. While at Biomodels, Dr. Lyng has optimized several rodent models of IBD (TNBS, DSS, and Oxazolone) and has introduced video endoscopy as a primary endpoint in determining disease severity as a more clinically-relevant endpoint than the traditional histopathology used in IBD models.

The PNAS manuscript can be read in its entirety  HERE.