Oral Health

Clinical Background

The mouth and its related structures represent a unique part of the human body. It is the only site in which two hard tissues (teeth and bone), different types of epithelium, and glandular tissue dynamically interact in an environment consisting of a myriad of microorganisms that is constantly bathed in a heterogeneous salivary fluid comprised of immunoglobulins, enzymes, and buffering agents. Furthermore, the heterogeneity of its composition predisposes the mouth to a wide range of infectious, neoplastic and autoimmune diseases which range broadly in their frequency, severity and impact. And the mucosa and bone are frequent targets of toxicities of a range of therapeutic modalities. Oral health provides opportunities for site specific agents as well as the potential for new and halo applications for existing drugs, biologicals and devices.

Preclinical Models

Biomodels’ scientists have demonstrated expertise and experience in modeling for a broad range of oral diseases from the most common (periodontal disease) to others that are more limited. Among these are:
• Periodontal disease
• Wound healing (both hard and soft tissue)
• Treatment of bony defects, extraction sites and residual ridge resorption
• Autoimmune diseases (aphthous stomatitis, lichen planus)
• Salivary gland disease
• Oral carcinogenesis (squamous cell carcinoma)
• Oral cancer
• Oral complications of cancer therapy (chemotherapy, radiation therapy, bisphosphonates, mTOR inhibitors)
• Genomics of oral disease (risk prediction, response/non-response, and mechanism of action)
Interested in one of these models? Please contact us directly!
Stephen T. Sonis, DMD, DMSc (Biomodels founder, Partner, Chief Scientific Officer)
2012 Received Distinguished Scientist Award in Oral Medicine and Pathology by the International Association for Dental Research.
Award Details